Loss of Smad4 Function in Pancreatic Tumors
نویسندگان
چکیده
منابع مشابه
Loss of Smad4 Function in Pancreatic Tumors
At early stages of tumorigenesis, the transforming growth factor(TGF) signaling pathway is thought to have tumor suppressor activity as a result of its ability to arrest the growth of epithelial cells. Smad4 plays a pivotal role in the TGFsignaling pathway and has been identified as a tumor suppressor, being mutated or deleted in 50% of pancreatic carcinomas and 15% of colorectal cancers. A non...
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15 صفحه اولClinicopathological significance of SMAD4 loss in pancreatic ductal adenocarcinomas: a systematic review and meta-analysis
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer mortality. Although advances have been made in understanding the pathogenesis of PDAC, the outcome still remains poor. The aim of this study is to conduct a meta-analysis to evaluate the precise association between SMAD4 loss and clinicopathological significance in PDAC. A literature search was made in PubMed, Web of...
متن کاملSmad4 Loss Synergizes with TGFα Overexpression in Promoting Pancreatic Metaplasia, PanIN Development, and Fibrosis
AIMS While overexpression of TGFα has been reported in human pancreatic ductal adenocarcinoma (PDAC), mice with overexpressed TGFα develop premalignant pancreatic acinar-to-ductal metaplasia (ADM) but not PDAC. TGF-β signaling pathway is pivotal to the development of PDAC and tissue fibrosis. Here we sought to investigate the interplay between TGFα and TGF-β signaling in pancreatic tumorigenesi...
متن کاملSMAD4/DPC4 and Pancreatic Cancer Survival
Pancreatic cancer is the fourth leading cause of cancer deaths in both men and women in the United States, accounting for 30,000 deaths annually. It is a deadly disease with a 5-year survival of only 3–5% (1). The diagnosis of pancreatic adenocarcinoma is devastating to patients and their families, because the diagnosis is usually made at a late stage of disease that is not amenable to cancer c...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m105895200